The Relationship of Estrogen and Cortisol to Prepulse Inhibition of the Acoustic Startle in Schizophrenia

this approach, we have recently identified the histamine HI-receptor as a likely proximal molecular target for atypical antipsychtoic drug-induced weight gain (Kroeze et al, Neuropsychopharmacol, in press) and are currently using datamining technologies to discover sites responsible for other actions of atypical antipsychotic drugs. We have also recently discovered that the kappa opioid receptor represents a potential target for antipsychotic drug development based on the preferential actions of a novel hallucinogen at this site (Roth et al, PNAS, in press). It is likely that this massively parallel approach will allow for the discovery of additional novel molecular targets for antipsychotic drug actions and will clarify the targets responsible for serious side-effects associated with antipsychotic drug treatment.